Assay Detail
Binding
CHEMBL4236045
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Inhibition of HPGDS (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Amelioration of mechanism-based inactivation of CYP3A4 by a H-PGDS inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.09 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4247050 | — | — | 1 | 8.52 |
| CHEMBL4241885 | — | — | 1 | 8.22 |
| CHEMBL3181890 | — | — | 1 | 8.15 |
| CHEMBL4250602 | — | — | 1 | 8.10 |
| CHEMBL4242281 | — | — | 1 | 8.02 |
| CHEMBL4239352 | — | — | 1 | 8.00 |
| CHEMBL4244590 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4247050 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4241885 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3181890 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4250602 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4242281 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4239352 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4244590 | — | IC50 | = | 23.0 | nM | 7.64 |