Assay Detail
Binding
CHEMBL4236293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.28 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4237803 | — | — | 1 | 8.92 |
| CHEMBL4241370 | — | — | 1 | 8.52 |
| CHEMBL2105763 | QUISINOSTAT | 2.0 | 1 | 8.36 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.29 |
| CHEMBL4244764 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4237803 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4241370 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2105763 | QUISINOSTAT | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4244764 | — | Ki | = | 50.0 | nM | 7.30 |