Assay Detail
Functional
CHEMBL4236333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant rat Cb1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP levels
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oximes short-acting CB1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.65 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4240671 | — | — | 1 | 9.40 |
| CHEMBL4240996 | — | — | 1 | 9.24 |
| CHEMBL4242964 | — | — | 1 | 9.15 |
| CHEMBL4249729 | — | — | 1 | 9.05 |
| CHEMBL4237501 | — | — | 1 | 8.59 |
| CHEMBL559612 | CP-55940 | — | 1 | 8.52 |
| CHEMBL4249273 | — | — | 1 | 8.36 |
| CHEMBL4243768 | — | — | 1 | 7.90 |
| CHEMBL4244186 | — | — | 1 | 7.65 |
| CHEMBL4239190 | — | — | 1 | - |
| CHEMBL4245472 | — | — | 1 | - |
| CHEMBL4238778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4240671 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4240996 | — | EC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4242964 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4249729 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4237501 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL559612 | CP-55940 | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4249273 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4243768 | — | EC50 | = | 12.7 | nM | 7.90 |
| CHEMBL4244186 | — | EC50 | = | 22.4 | nM | 7.65 |
| CHEMBL4239190 | — | EC50 | - | — | - | |
| CHEMBL4245472 | — | EC50 | - | — | - | |
| CHEMBL4238778 | — | EC50 | - | — | - |