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Compound Detail

CHEMBL4237501

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CC1=CC[C@H]2[C@H](C1)c1c(O)cc(/C(C)=N/OCCCc3ccccc3)cc1OC2(C)C

Basic Information

ChEMBL ID CHEMBL4237501
Phase Preclinical
Structure Type MOL
InChI Key DDDWBLNFJLSGSY-KOONVYFQSA-N
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

419.6
MW (Da)
6.38
ALogP
4
HBA
1
HBD
51.0
PSA (Ų)
0.26
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H33NO3
MW 419.57
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness 1.19

Activity Summary

Ki 3 meas. best 8.57
EC50 2 meas. best 8.78

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
EC50 8.78 8.78 1.6 1
Cannabinoid receptor 1
CHEMBL3571
EC50 8.59 8.59 2.6 1
Cannabinoid receptor 2
CHEMBL253
Ki 8.57 8.57 2.7 1
Cannabinoid receptor 1
CHEMBL3571
Ki 8.52 8.52 3.0 1
Cannabinoid receptor 2
CHEMBL5373
Ki 8.42 8.42 3.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30122284 10.1016/j.bmc.2018.08.003 Cannabinoid receptor 2 4
30122284 10.1016/j.bmc.2018.08.003 Cannabinoid receptor 1 3

Data from ChEMBL 36 via Core Engine