Assay Detail
Functional
CHEMBL4236334
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Agonist activity at recombinant human Cb2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP levels
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oximes short-acting CB1 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.16 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4240671 | — | — | 1 | 9.00 |
| CHEMBL4237501 | — | — | 1 | 8.78 |
| CHEMBL4245472 | — | — | 1 | 8.77 |
| CHEMBL559612 | CP-55940 | — | 1 | 8.70 |
| CHEMBL4239190 | — | — | 1 | 8.70 |
| CHEMBL4240996 | — | — | 1 | 8.04 |
| CHEMBL4238778 | — | — | 1 | 7.94 |
| CHEMBL4249273 | — | — | 1 | 7.92 |
| CHEMBL4244186 | — | — | 1 | 7.38 |
| CHEMBL4249729 | — | — | 1 | 7.30 |
| CHEMBL4243768 | — | — | 1 | 7.18 |
| CHEMBL4242964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4240671 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4237501 | — | EC50 | = | 1.65 | nM | 8.78 |
| CHEMBL4245472 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL559612 | CP-55940 | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4239190 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4240996 | — | EC50 | = | 9.14 | nM | 8.04 |
| CHEMBL4238778 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL4249273 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4244186 | — | EC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4249729 | — | EC50 | = | 49.6 | nM | 7.30 |
| CHEMBL4243768 | — | EC50 | = | 65.7 | nM | 7.18 |
| CHEMBL4242964 | — | EC50 | - | — | - |