Assay Detail
Functional
CHEMBL4252250
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Antiinflammatory activity in LPS/IFNgamma-differentiated Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced IL-1beta release preincubated for 15 mins followed by ATP/LPS challenge measured after 30 mins by sandwich ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.45 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281588 | — | — | 1 | 7.95 |
| CHEMBL4292211 | — | — | 1 | 7.31 |
| CHEMBL4291798 | — | — | 1 | 6.17 |
| CHEMBL255787 | — | — | 1 | 6.14 |
| CHEMBL4173394 | BRILLIANT BLUE G | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281588 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL4292211 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL4291798 | — | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL255787 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL4173394 | BRILLIANT BLUE G | IC50 | = | 19770.0 | nM | 4.70 |