Assay Detail
Binding
CHEMBL4252297
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Inhibition of DENV3 NS5 RdRp using ss-RNA PolyC as template and GTP as substrate assessed as decrease in dsRNA levels after 1 hr by PicoGreen-based fluorescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.12 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288319 | — | — | 1 | 6.22 |
| CHEMBL4292407 | — | — | 1 | 6.05 |
| CHEMBL4281417 | — | — | 1 | 5.77 |
| CHEMBL4279581 | — | — | 1 | 5.58 |
| CHEMBL4289289 | — | — | 1 | 5.35 |
| CHEMBL4284511 | — | — | 1 | 5.33 |
| CHEMBL4281097 | — | — | 1 | 5.33 |
| CHEMBL4284513 | — | — | 1 | 5.20 |
| CHEMBL4280007 | — | — | 1 | 5.16 |
| CHEMBL4281094 | — | — | 1 | 5.16 |
| CHEMBL4295172 | — | — | 1 | 5.16 |
| CHEMBL4289005 | — | — | 1 | 5.08 |
| CHEMBL4291308 | — | — | 1 | 4.94 |
| CHEMBL3233235 | — | — | 1 | 4.87 |
| CHEMBL3233241 | — | — | 1 | 4.85 |
| CHEMBL4277678 | — | — | 1 | 4.80 |
| CHEMBL2326938 | — | — | 1 | 4.76 |
| CHEMBL4291731 | — | — | 1 | 4.69 |
| CHEMBL4287909 | — | — | 1 | 4.51 |
| CHEMBL4277265 | — | — | 1 | 4.38 |
| CHEMBL4280662 | — | — | 1 | 4.33 |
| CHEMBL4287912 | — | — | 1 | - |
| CHEMBL4287491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288319 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4292407 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4281417 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4279581 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4289289 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4284511 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4281097 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4284513 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4280007 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4281094 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4295172 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4289005 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4291308 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3233235 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3233241 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4277678 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL2326938 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4291731 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4287909 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL4277265 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL4280662 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL4287912 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4287491 | — | IC50 | > | 50000.0 | nM | - |