Assay Detail
Functional
CHEMBL4252547
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Antiproliferative activity against human A2780/DX cells after 72 hrs by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Camptothecin-psammaplin A hybrids as topoisomerase I and HDAC dual-action inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.52 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290191 | — | — | 1 | 6.08 |
| CHEMBL4276867 | — | — | 1 | 5.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.48 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.70 |
| CHEMBL4280303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290191 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4276867 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4280303 | — | IC50 | - | — | - |