Assay Detail
Functional
CHEMBL4252554
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Antiproliferative activity against human KM-H2 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM-H2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Camptothecin-psammaplin A hybrids as topoisomerase I and HDAC dual-action inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.18 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290191 | — | — | 1 | 6.55 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.81 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290191 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL481 | IRINOTECAN | IC50 | > | 10000.0 | nM | - |