Assay Detail
ADMET
CHEMBL4253162
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Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nontoxic combretafuranone analogues with high in vitro antibacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.79 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.16 |
| CHEMBL4277580 | — | — | 1 | 6.36 |
| CHEMBL4291642 | — | — | 1 | 6.27 |
| CHEMBL3357105 | — | — | 1 | 5.66 |
| CHEMBL4284409 | — | — | 1 | 5.58 |
| CHEMBL4290802 | — | — | 1 | 5.56 |
| CHEMBL4292758 | — | — | 1 | 5.53 |
| CHEMBL3357099 | — | — | 1 | 5.12 |
| CHEMBL4277638 | — | — | 1 | 4.90 |
| CHEMBL4291691 | — | — | 1 | - |
| CHEMBL4287389 | — | — | 1 | - |
| CHEMBL4279022 | — | — | 1 | - |
| CHEMBL4280728 | — | — | 1 | - |
| CHEMBL4287821 | — | — | 1 | - |
| CHEMBL3357095 | — | — | 1 | - |
| CHEMBL4284035 | — | — | 1 | - |
| CHEMBL4294632 | — | — | 1 | - |
| CHEMBL4288226 | — | — | 1 | - |
| CHEMBL4292695 | — | — | 1 | - |
| CHEMBL4288276 | — | — | 1 | - |
| CHEMBL4284889 | — | — | 1 | - |
| CHEMBL4289347 | — | — | 1 | - |
| CHEMBL4281465 | — | — | 1 | - |
| CHEMBL4294684 | — | — | 1 | - |
| CHEMBL4286781 | — | — | 1 | - |
| CHEMBL4292018 | — | — | 1 | - |
| CHEMBL4286357 | — | — | 1 | - |
| CHEMBL4288600 | — | — | 1 | - |
| CHEMBL4280583 | — | — | 1 | - |
| CHEMBL4291230 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4277580 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4291642 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3357105 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4284409 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4290802 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4292758 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL3357099 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL4277638 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4287389 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4279480 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4279022 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4280728 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4287821 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3357095 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4284035 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4294632 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4288226 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4292695 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4284826 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4282943 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4291691 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4288276 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4284889 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4289347 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4281465 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4294684 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4286781 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4292018 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4286357 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4288600 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4280583 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4291230 | — | IC50 | > | 40000.0 | nM | - |