Assay Detail
Functional
CHEMBL4253572
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Antiproliferative activity against human U87MG cells after 72 hrs by DAPI staining based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.57 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277900 | CROZBACICLIB | 2.0 | 1 | 7.82 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277900 | CROZBACICLIB | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 48.1 | nM | 7.32 |