Assay Detail
Binding
CHEMBL4253918
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PTP1B using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.25 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1808155 | CHALCOMORACIN | — | 1 | 5.71 |
| CHEMBL4290098 | — | — | 1 | 5.59 |
| CHEMBL220746 | CUDRAFLAVANONE A | — | 1 | 5.37 |
| CHEMBL4279417 | — | — | 1 | 5.34 |
| CHEMBL463145 | NORARTOCARPETIN | — | 1 | 5.29 |
| CHEMBL4291588 | — | — | 1 | 5.10 |
| CHEMBL464006 | MORUSIN | — | 1 | 4.99 |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1808155 | CHALCOMORACIN | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4290098 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL220746 | CUDRAFLAVANONE A | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4279417 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL463145 | NORARTOCARPETIN | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4291588 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL464006 | MORUSIN | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL43065 | OXYRESVERATROL | IC50 | = | 27130.0 | nM | 4.57 |