Assay Detail
Binding
CHEMBL4254545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by TopCount scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.95 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291322 | — | — | 1 | 9.28 |
| CHEMBL4285796 | — | — | 1 | 8.25 |
| CHEMBL4278933 | — | — | 1 | 8.09 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.02 |
| CHEMBL4286174 | — | — | 1 | 7.89 |
| CHEMBL4288120 | — | — | 1 | 7.82 |
| CHEMBL4277476 | — | — | 1 | 7.75 |
| CHEMBL4294077 | — | — | 1 | 7.60 |
| CHEMBL4289783 | — | — | 1 | 7.55 |
| CHEMBL4289605 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291322 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL4285796 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL4278933 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL2104993 | VORTIOXETINE | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL4286174 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4288120 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4277476 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4294077 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4289783 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL4289605 | — | Ki | = | 62.0 | nM | 7.21 |