Assay Detail
Functional
CHEMBL4254777
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Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) harboring neuraminidase H275Y mutant infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs by CellTiter96 Aqueous non-radioactive cell proliferation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Peramivir conjugates as orally available agents against influenza H275Y mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.67 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288995 | — | — | 1 | 7.81 |
| CHEMBL4288789 | — | — | 1 | 7.74 |
| CHEMBL4278125 | — | — | 1 | 7.14 |
| CHEMBL4293261 | — | — | 1 | 6.39 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 6.19 |
| CHEMBL4285430 | — | — | 1 | 6.00 |
| CHEMBL4280263 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288995 | — | EC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4288789 | — | EC50 | = | 18.1 | nM | 7.74 |
| CHEMBL4278125 | — | EC50 | = | 71.6 | nM | 7.14 |
| CHEMBL4293261 | — | EC50 | = | 405.0 | nM | 6.39 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | EC50 | = | 643.0 | nM | 6.19 |
| CHEMBL4285430 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4280263 | — | EC50 | = | 3520.0 | nM | 5.45 |