Assay Detail
Binding
CHEMBL4254780
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Inhibition of Influenza A virus (A/WSN/1933(H1N1)) recombinant neuraminidase H275Y mutant expressed in HEK293 cells pre-incubated for 10 mins before 4-MUNANA substrate addition by fluorometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/WSN/1933(H1N1)) |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Peramivir conjugates as orally available agents against influenza H275Y mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.26 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 1 | 8.44 |
| CHEMBL4288789 | — | — | 1 | 8.28 |
| CHEMBL4288995 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4288789 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4288995 | — | IC50 | = | 8.6 | nM | 8.07 |