Assay Detail
Functional
CHEMBL4254891
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Cytotoxicity against human HL60 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, anticancer activity and mechanism of action of new thiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.15 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.72 |
| CHEMBL4287619 | — | — | 1 | 5.43 |
| CHEMBL4286552 | — | — | 1 | 5.37 |
| CHEMBL4294855 | — | — | 1 | 4.94 |
| CHEMBL4286224 | — | — | 1 | 4.93 |
| CHEMBL2369206 | — | — | 1 | 4.89 |
| CHEMBL4293246 | — | — | 1 | 4.76 |
| CHEMBL4279709 | — | — | 1 | 4.75 |
| CHEMBL4284233 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4287619 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4286552 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL4294855 | — | IC50 | = | 11510.0 | nM | 4.94 |
| CHEMBL4286224 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL2369206 | — | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL4293246 | — | IC50 | = | 17220.0 | nM | 4.76 |
| CHEMBL4279709 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4284233 | — | IC50 | = | 29290.0 | nM | 4.53 |