Assay Detail
Functional
CHEMBL4255375
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Cytotoxicity against CD133 positive human HCT116 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.32 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551337 | — | — | 1 | 9.85 |
| CHEMBL4292039 | — | — | 1 | 9.62 |
| CHEMBL126916 | — | — | 1 | 9.55 |
| CHEMBL339370 | — | — | 1 | 9.08 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.49 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.47 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.11 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551337 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4292039 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL126916 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL339370 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 451.0 | nM | 6.35 |