Assay Detail
Binding
CHEMBL4255706
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Binding affinity to Influenza A virus A/Udorn/72 wild-type M2 proton channel by isothermal calorimetric titration
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.09 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277543 | — | — | 1 | 6.89 |
| CHEMBL1235691 | — | — | 1 | 6.50 |
| CHEMBL3392935 | — | — | 1 | 6.47 |
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 6.29 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.66 |
| CHEMBL4292664 | — | — | 1 | 5.46 |
| CHEMBL4284791 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277543 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL1235691 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL3392935 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL959 | RIMANTADINE | Kd | = | 510.0 | nM | 6.29 |
| CHEMBL660 | AMANTADINE | Kd | = | 2170.0 | nM | 5.66 |
| CHEMBL4292664 | — | Kd | = | 3430.0 | nM | 5.46 |
| CHEMBL4284791 | — | Kd | = | 4590.0 | nM | 5.34 |