Assay Detail
Binding
CHEMBL4255808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus LAC USA300 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus USA300 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) (CHEMBL3832958) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain MW2) |
Publication
Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.26 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284707 | — | — | 1 | 8.43 |
| CHEMBL4288408 | — | — | 1 | 8.26 |
| CHEMBL4278050 | — | — | 1 | 8.23 |
| CHEMBL3827961 | — | — | 1 | 8.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284707 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4288408 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4278050 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3827961 | — | IC50 | = | 7.7 | nM | 8.11 |