Assay Detail
Functional
CHEMBL4255997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reactivation of latent HIV1 infected in human U1 cells assessed as increase in p24 production after 48 hrs by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.16 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501600 | GNIDIMACRIN | — | 1 | 10.74 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 8.96 |
| CHEMBL1863513 | INGENOL MEBUTATE | 4.0 | 1 | 8.32 |
| CHEMBL3622374 | — | — | 1 | 6.22 |
| CHEMBL235842 | — | — | 1 | 6.03 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.92 |
| CHEMBL4087968 | — | — | 1 | 5.85 |
| CHEMBL4282815 | — | — | 1 | 5.24 |
| CHEMBL4078477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501600 | GNIDIMACRIN | EC50 | = | 0.018 | nM | 10.74 |
| CHEMBL343448 | ROMIDEPSIN | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1863513 | INGENOL MEBUTATE | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3622374 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL235842 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4087968 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4282815 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4078477 | — | EC50 | - | — | - |