Assay Detail
Functional
CHEMBL4256489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.71 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4294880 | — | — | 1 | 8.92 |
| CHEMBL4279732 | — | — | 1 | 8.89 |
| CHEMBL4287637 | — | — | 1 | 8.70 |
| CHEMBL4289474 | — | — | 1 | 8.64 |
| CHEMBL4285119 | — | — | 1 | 8.52 |
| CHEMBL4292630 | — | — | 1 | 8.49 |
| CHEMBL4289210 | — | — | 1 | 8.46 |
| CHEMBL4288817 | — | — | 1 | 8.05 |
| CHEMBL4280917 | — | — | 1 | 7.70 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.37 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.24 |
| CHEMBL4278559 | — | — | 1 | 6.68 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.33 |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 6.32 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4294880 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4279732 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4287637 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4289474 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4285119 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4292630 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4289210 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4288817 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4280917 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4278559 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1540 | PENCICLOVIR | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 4180.0 | nM | 5.38 |