Assay Detail
Functional
CHEMBL4256490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against ACV-resistant thymidine kinase deficient Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect measured after 2 to 3 days post-infection
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.21 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4289474 | — | — | 1 | 9.05 |
| CHEMBL4294880 | — | — | 1 | 8.92 |
| CHEMBL4279732 | — | — | 1 | 8.89 |
| CHEMBL4289210 | — | — | 1 | 8.82 |
| CHEMBL4285119 | — | — | 1 | 8.74 |
| CHEMBL4287637 | — | — | 1 | 8.72 |
| CHEMBL4288817 | — | — | 1 | 8.24 |
| CHEMBL4292630 | — | — | 1 | 8.14 |
| CHEMBL4280917 | — | — | 1 | 8.00 |
| CHEMBL4278559 | — | — | 1 | 7.12 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.71 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4289474 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4294880 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4279732 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4289210 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4285119 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4287637 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4288817 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4292630 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4280917 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4278559 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL184 | ACYCLOVIR | EC50 | > | 88800.0 | nM | - |
| CHEMBL1540 | PENCICLOVIR | EC50 | > | 79000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | EC50 | > | 30000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | > | 29500.0 | nM | - |