Assay Detail

CHEMBL4256569

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ADMET

Cytotoxicity against HEK293 cells after 72 hrs by fluorescence assay

ChEMBL ↗

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Target

HEK293 (CHEMBL614818) ↗

Open DB target context

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Primary target HEK293

CHEMBL614818

Anchored from Assay target.

Protein identity HEK293

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	HEK293
Confidence	1 — Organism
Curated By	Intermediate

Target

HEK293 (CHEMBL614818) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

The Notch Inhibitors Isolated from Nerium indicum.

Arai MA, Akamine R, Hayashi N, Koyano T, Kowithayakorn T, Ishibashi M.
J Nat Prod (2018) 81 : 1235 -1240
PubMed 29693393 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.55	7.55

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4285883	OLEANDRIN	1.0	1	7.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4285883	OLEANDRIN	IC50	=	28.0	nM	7.55