Assay Detail
Binding
CHEMBL4256752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction in LPS-stimulated IL-1beta levels pre-incubated with LPS for 4.5 hrs followed by incubation for 30 mins in presence of ATP and measured after 30 mins by ELISA
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL3779755) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.49 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278966 | — | — | 1 | 6.38 |
| CHEMBL4277889 | — | — | 1 | 6.26 |
| CHEMBL4289639 | — | — | 1 | 6.20 |
| CHEMBL4293687 | — | — | 1 | 6.09 |
| CHEMBL4285824 | — | — | 1 | 6.01 |
| CHEMBL4286218 | — | — | 1 | 5.88 |
| CHEMBL4293025 | — | — | 1 | 5.85 |
| CHEMBL4277518 | — | — | 1 | 5.82 |
| CHEMBL4282420 | — | — | 1 | 5.79 |
| CHEMBL4283094 | — | — | 1 | 5.78 |
| CHEMBL4291357 | — | — | 1 | 5.76 |
| CHEMBL4288157 | — | — | 1 | 5.72 |
| CHEMBL4284271 | — | — | 1 | 5.70 |
| CHEMBL4283514 | — | — | 1 | 5.69 |
| CHEMBL4294115 | — | — | 1 | 5.68 |
| CHEMBL4277456 | — | — | 1 | 5.49 |
| CHEMBL4286869 | — | — | 1 | 5.47 |
| CHEMBL4294769 | — | — | 1 | 5.46 |
| CHEMBL4290279 | — | — | 1 | 5.45 |
| CHEMBL4279617 | — | — | 1 | 5.30 |
| CHEMBL4280865 | — | — | 1 | 5.23 |
| CHEMBL4292588 | — | — | 1 | 4.98 |
| CHEMBL4281291 | — | — | 1 | 4.87 |
| CHEMBL4289169 | — | — | 1 | 4.77 |
| CHEMBL4277453 | — | — | 1 | 4.74 |
| CHEMBL4288097 | — | — | 1 | 4.50 |
| CHEMBL4294904 | — | — | 1 | 4.49 |
| CHEMBL4291505 | — | — | 1 | 4.35 |
| CHEMBL4284698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278966 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4277889 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4289639 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4293687 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4285824 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4286218 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4293025 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4277518 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4282420 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4283094 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4291357 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4288157 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4284271 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4283514 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4294115 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4277456 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL4286869 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4294769 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL4290279 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4279617 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL4280865 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL4292588 | — | IC50 | = | 10480.0 | nM | 4.98 |
| CHEMBL4281291 | — | IC50 | = | 13360.0 | nM | 4.87 |
| CHEMBL4289169 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4277453 | — | IC50 | = | 18031.0 | nM | 4.74 |
| CHEMBL4288097 | — | IC50 | = | 31780.0 | nM | 4.50 |
| CHEMBL4294904 | — | IC50 | = | 32750.0 | nM | 4.49 |
| CHEMBL4291505 | — | IC50 | = | 44420.0 | nM | 4.35 |
| CHEMBL4284698 | — | IC50 | = | 146560.0 | nM | - |