Assay Detail
Binding
CHEMBL4256957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human membrane bound C-terminal His4-tagged CYP17A1 delta19H mutant assessed as reduction in progesterone hydroxylation preincubated for 3 mins followed by NADPH addition measured after 10 mins in presence of NADPH-cytochrome p450 reductase by HPLC method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of cyp17a1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.35 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4210141 | — | — | 1 | 6.92 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 6.89 |
| CHEMBL4280255 | — | — | 1 | 6.82 |
| CHEMBL4209941 | — | — | 1 | 6.76 |
| CHEMBL4293668 | — | — | 1 | 6.74 |
| CHEMBL4289220 | — | — | 1 | 6.70 |
| CHEMBL4209916 | — | — | 1 | 6.68 |
| CHEMBL4279184 | — | — | 1 | 6.61 |
| CHEMBL2105738 | GALETERONE | 3.0 | 1 | 6.55 |
| CHEMBL4294403 | — | — | 1 | 6.37 |
| CHEMBL4276910 | — | — | 1 | 5.86 |
| CHEMBL4288206 | — | — | 1 | 5.40 |
| CHEMBL1921976 | ORTERONEL | 3.0 | 1 | 5.33 |
| CHEMBL4210952 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4210141 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4280255 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4209941 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4293668 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4289220 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL4209916 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4279184 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL2105738 | GALETERONE | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL4294403 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4276910 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4288206 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL1921976 | ORTERONEL | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL4210952 | — | IC50 | = | 5410.0 | nM | 5.27 |