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Assay Detail

CHEMBL4256960

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Binding
Inhibition of c-fms (unknown origin) assessed as inhibition of CSF-1R phosphorylation of tyrosine on synthetic CSF-1R (555 to 568) peptide using 1 nM enzyme incubated for 80 mins by fluorescence polarization competition immunoassay
ChEMBL ↗
86
Total Activities
86
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of c-fms kinase
(2016)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 86 8.40 9.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3086320 — — 1 9.36
CHEMBL4282165 — — 1 9.29
CHEMBL4294553 — — 1 9.22
CHEMBL3085973 — — 1 9.19
CHEMBL3085977 — — 1 9.17
CHEMBL3086324 — — 1 9.16
CHEMBL4295208 — — 1 9.12
CHEMBL4294739 — — 1 9.10
CHEMBL4292129 — — 1 9.10
CHEMBL4280188 — — 1 9.09
CHEMBL3085833 — — 1 9.06
CHEMBL4286584 — — 1 9.03
CHEMBL3085828 — — 1 9.03
CHEMBL3660762 — — 1 8.96
CHEMBL3086317 — — 1 8.92
CHEMBL3085976 — — 1 8.92
CHEMBL4286210 — — 1 8.89
CHEMBL3639596 — — 1 8.89
CHEMBL3085834 — — 1 8.89
CHEMBL4286176 — — 1 8.85
CHEMBL3660763 — — 1 8.85
CHEMBL3085831 — — 1 8.82
CHEMBL3660801 — — 1 8.82
CHEMBL3967115 — — 1 8.82
CHEMBL4281126 — — 1 8.80
CHEMBL3085974 — — 1 8.80
CHEMBL3085832 — — 1 8.77
CHEMBL3660800 — — 1 8.77
CHEMBL3085981 — — 1 8.77
CHEMBL3086321 — — 1 8.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3086320 — IC50 = 0.44 nM 9.36
CHEMBL4282165 — IC50 = 0.51 nM 9.29
CHEMBL4294553 — IC50 = 0.6 nM 9.22
CHEMBL3085973 — IC50 = 0.64 nM 9.19
CHEMBL3085977 — IC50 = 0.68 nM 9.17
CHEMBL3086324 — IC50 = 0.69 nM 9.16
CHEMBL4295208 — IC50 = 0.75 nM 9.12
CHEMBL4294739 — IC50 = 0.8 nM 9.10
CHEMBL4292129 — IC50 = 0.8 nM 9.10
CHEMBL4280188 — IC50 = 0.82 nM 9.09
CHEMBL3085833 — IC50 = 0.88 nM 9.06
CHEMBL4286584 — IC50 = 0.93 nM 9.03
CHEMBL3085828 — IC50 = 0.94 nM 9.03
CHEMBL3660762 — IC50 = 1.1 nM 8.96
CHEMBL3085976 — IC50 = 1.2 nM 8.92
CHEMBL3086317 — IC50 = 1.2 nM 8.92
CHEMBL4286210 — IC50 = 1.3 nM 8.89
CHEMBL3639596 — IC50 = 1.3 nM 8.89
CHEMBL3085834 — IC50 = 1.3 nM 8.89
CHEMBL4286176 — IC50 = 1.43 nM 8.85
CHEMBL3660763 — IC50 = 1.4 nM 8.85
CHEMBL3085831 — IC50 = 1.5 nM 8.82
CHEMBL3660801 — IC50 = 1.5 nM 8.82
CHEMBL3967115 — IC50 = 1.5 nM 8.82
CHEMBL3085974 — IC50 = 1.6 nM 8.80
CHEMBL4281126 — IC50 = 1.6 nM 8.80
CHEMBL3085832 — IC50 = 1.7 nM 8.77
CHEMBL3660800 — IC50 = 1.7 nM 8.77
CHEMBL3085981 — IC50 = 1.7 nM 8.77
CHEMBL3086321 — IC50 = 1.7 nM 8.77
CHEMBL3086322 — IC50 = 1.8 nM 8.74
CHEMBL3086318 — IC50 = 1.9 nM 8.72
CHEMBL3660796 — IC50 = 2.0 nM 8.70
CHEMBL3085975 — IC50 = 2.0 nM 8.70
CHEMBL4293523 — IC50 = 2.4 nM 8.62
CHEMBL3660781 — IC50 = 2.5 nM 8.60
CHEMBL3660768 — IC50 = 2.6 nM 8.59
CHEMBL3085980 — IC50 = 2.7 nM 8.57
CHEMBL3085830 — IC50 = 2.9 nM 8.54
CHEMBL4288418 — IC50 = 2.9 nM 8.54
CHEMBL3660766 — IC50 = 2.9 nM 8.54
CHEMBL3086179 — IC50 = 3.2 nM 8.49
CHEMBL3085829 — IC50 = 3.3 nM 8.48
CHEMBL3085972 — IC50 = 3.5 nM 8.46
CHEMBL4285243 — IC50 = 3.9 nM 8.41
CHEMBL3889904 — IC50 = 3.9 nM 8.41
CHEMBL4289455 — IC50 = 4.4 nM 8.36
CHEMBL3086314 — IC50 = 4.5 nM 8.35
CHEMBL4293513 — IC50 = 4.6 nM 8.34
CHEMBL3660753 — IC50 = 4.7 nM 8.33