Assay Detail
Binding
CHEMBL4257015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDH2 R140Q mutant homodimer (unknown origin) expressed in Sf9 cells pre-incubated for 6 hrs before addition of alpha-KG followed by 60 mins incubation in presence of NADPH, NADP, diaphorase and resazurin by fluorescence spectrometry based cofactor depletion assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Isocitrate dehydrogenase [NADP], mitochondrial (CHEMBL3991501) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutically active compounds and their methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.13 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278435 | — | — | 1 | 7.30 |
| CHEMBL4277108 | — | — | 1 | 7.30 |
| CHEMBL4284203 | — | — | 1 | 7.30 |
| CHEMBL4282925 | — | — | 1 | 7.30 |
| CHEMBL4286667 | — | — | 1 | 7.30 |
| CHEMBL4281594 | — | — | 1 | 7.30 |
| CHEMBL4290554 | — | — | 1 | 7.30 |
| CHEMBL4285495 | — | — | 1 | 7.30 |
| CHEMBL4278414 | — | — | 1 | 7.00 |
| CHEMBL4286947 | — | — | 1 | 7.00 |
| CHEMBL4294899 | — | — | 1 | 7.00 |
| CHEMBL4288016 | — | — | 1 | 7.00 |
| CHEMBL4292464 | — | — | 1 | 7.00 |
| CHEMBL4283985 | — | — | 1 | 7.00 |
| CHEMBL4285110 | — | — | 1 | 7.00 |
| CHEMBL4284068 | — | — | 1 | 7.00 |
| CHEMBL4277506 | — | — | 1 | 7.00 |
| CHEMBL4278807 | — | — | 1 | 7.00 |
| CHEMBL4287037 | — | — | 1 | - |
| CHEMBL4290450 | — | — | 1 | - |
| CHEMBL4288655 | — | — | 1 | - |
| CHEMBL4289486 | — | — | 1 | - |
| CHEMBL4280213 | — | — | 1 | - |
| CHEMBL4281221 | — | — | 1 | - |
| CHEMBL4277498 | — | — | 1 | - |
| CHEMBL4294615 | — | — | 1 | - |
| CHEMBL4282989 | — | — | 1 | - |
| CHEMBL4282906 | — | — | 1 | - |
| CHEMBL4291028 | — | — | 1 | - |
| CHEMBL4292328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278435 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4277108 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4284203 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4282925 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4286667 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4281594 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4290554 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4285495 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4294899 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4286947 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4278414 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4288016 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4292464 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4283985 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4285110 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4284068 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4277506 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4278807 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4280132 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4283138 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4287037 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4290450 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4288655 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4289486 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4280213 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4281221 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4277498 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4294615 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4282989 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4282906 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4291028 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4292328 | — | IC50 | >= | 1000.0 | nM | - |