Assay Detail
Binding
CHEMBL4257128
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Inhibition of NHE1 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Nhe3-binding compounds and methods for inhibiting phosphate transport
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.34 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3900790 | — | — | 1 | 9.00 |
| CHEMBL3900457 | — | — | 1 | 8.70 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | 8.30 |
| CHEMBL51879 | — | — | 1 | 8.05 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 7.52 |
| CHEMBL355862 | ZONIPORIDE | 2.0 | 1 | 7.23 |
| CHEMBL3897683 | — | — | 1 | 5.44 |
| CHEMBL3974005 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3900790 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3900457 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL64360 | ENIPORIDE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL51879 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL355862 | ZONIPORIDE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3897683 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3974005 | — | IC50 | = | 35000.0 | nM | 4.46 |