Assay Detail
Binding
CHEMBL4257981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP1A1 expressed in adherent HEK293 cells assessed as protection of cells against CYP1A1-mediated sensitivity to to B[a]P-induced cytotoxicity by measuring B[a]P- EC50 by MTT assay (Rvb = 0.8 +/- 0.1 uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy <i>via</i> screening of a natural product repository.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.16 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 5.75 |
| CHEMBL4282750 | — | — | 1 | 4.87 |
| CHEMBL140796 | ISOPIMPINELLIN | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4282750 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL140796 | ISOPIMPINELLIN | EC50 | = | 13800.0 | nM | 4.86 |