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Assay Detail

CHEMBL4258445

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Functional
Antiproliferative activity against human U87 cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-87MG ATCC
Confidence 1 — Organism
Curated By Intermediate

Target

U-87 MG (CHEMBL614247)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4<i>H</i>-pyran-4-one derivatives as antiglioma agents.
Li YB, Hou W, Lin H, Sun PH, Lin J, Chen WM.
Medchemcomm (2018) 9 : 471 -476
PubMed 30108937 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.82 5.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4286032 1 5.34
CHEMBL4278116 1 5.28
CHEMBL2180727 1 4.70
CHEMBL4286444 1 4.57
CHEMBL4279183 1 4.53
CHEMBL4289867 1 4.51
CHEMBL4294325 1 -
CHEMBL4293250 1 -
CHEMBL4282653 1 -
CHEMBL4291032 1 -
CHEMBL4280398 1 -
CHEMBL4280797 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4286032 IC50 = 4600.0 nM 5.34
CHEMBL4278116 IC50 = 5200.0 nM 5.28
CHEMBL2180727 IC50 = 20100.0 nM 4.70
CHEMBL4286444 IC50 = 27200.0 nM 4.57
CHEMBL4279183 IC50 = 29500.0 nM 4.53
CHEMBL4289867 IC50 = 30900.0 nM 4.51
CHEMBL4294325 IC50 > 50000.0 nM -
CHEMBL4293250 IC50 > 50000.0 nM -
CHEMBL4282653 IC50 > 50000.0 nM -
CHEMBL4291032 IC50 > 50000.0 nM -
CHEMBL4280398 IC50 > 50000.0 nM -
CHEMBL4280797 IC50 > 50000.0 nM -