Assay Detail
Functional
CHEMBL4259331
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Antiviral activity against HIV-1 subtype B HXB2 pseudovirus assessed as inhibition of viral infection in Ghost (3)X4/R5 cells after 48 hrs by Bright-Glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Generation of a long-acting fusion inhibitor against HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.41 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281745 | — | — | 1 | 10.30 |
| CHEMBL4287830 | — | — | 1 | 9.40 |
| CHEMBL4277174 | — | — | 1 | 9.30 |
| CHEMBL4289957 | — | — | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281745 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4287830 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4277174 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4289957 | — | IC50 | = | 2.4 | nM | 8.62 |