Assay Detail
Binding
CHEMBL4259388
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Agonist activity at human Gal4-fused RXRgamma expressed in HEK293T cells after 12 to 14 hrs by dual-Glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Scaffold hopping from synthetic RXR modulators by virtual screening and <i>de novo</i> design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.63 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281062 | — | — | 1 | 4.85 |
| CHEMBL4277640 | — | — | 1 | 4.77 |
| CHEMBL4277218 | — | — | 1 | 4.62 |
| CHEMBL4094117 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281062 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4277640 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4277218 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4094117 | — | EC50 | = | 51000.0 | nM | 4.29 |