Assay Detail
Binding
CHEMBL4259693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1 (unknown origin) using biotin-labelled STK as substrate measured after 45 mins by HTRF method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of AKT inhibitors bearing a piperidin-4-yl appendant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.47 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 7.67 |
| CHEMBL4285143 | — | — | 1 | 7.61 |
| CHEMBL4281435 | — | — | 1 | 7.57 |
| CHEMBL4284849 | — | — | 1 | 7.52 |
| CHEMBL4282775 | — | — | 1 | 7.48 |
| CHEMBL4292059 | — | — | 1 | 7.29 |
| CHEMBL4284420 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494089 | GSK-690693 | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL4285143 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL4281435 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL4284849 | — | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL4282775 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL4292059 | — | IC50 | = | 51.9 | nM | 7.29 |
| CHEMBL4284420 | — | IC50 | = | 66.6 | nM | 7.18 |