Assay Detail
Binding
CHEMBL4259803
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Inhibition of human topoisomerase-2 assessed as reduction in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromide staining based agarose gel electrophoresis method
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.42 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291901 | — | — | 1 | 4.80 |
| CHEMBL4284048 | — | — | 1 | 4.39 |
| CHEMBL4280052 | — | — | 1 | 4.37 |
| CHEMBL4278165 | — | — | 1 | 4.12 |
| CHEMBL4290522 | — | — | 1 | - |
| CHEMBL259761 | — | — | 1 | - |
| CHEMBL4283334 | — | — | 1 | - |
| CHEMBL4293926 | — | — | 1 | - |
| CHEMBL4285482 | — | — | 1 | - |
| CHEMBL4278775 | — | — | 1 | - |
| CHEMBL4290114 | — | — | 1 | - |
| CHEMBL4282248 | — | — | 1 | - |
| CHEMBL4283977 | — | — | 1 | - |
| CHEMBL4291839 | — | — | 1 | - |
| CHEMBL1543210 | — | — | 1 | - |
| CHEMBL4282057 | — | — | 1 | - |
| CHEMBL4289927 | — | — | 1 | - |
| CHEMBL1451226 | — | — | 1 | - |
| CHEMBL4287101 | — | — | 1 | - |
| CHEMBL4295028 | — | — | 1 | - |
| CHEMBL4280175 | — | — | 1 | - |
| CHEMBL1529748 | — | — | 1 | - |
| CHEMBL4289111 | — | — | 1 | - |
| CHEMBL4294214 | — | — | 1 | - |
| CHEMBL4276745 | — | — | 1 | - |
| CHEMBL2170108 | — | — | 1 | - |
| CHEMBL4285122 | — | — | 1 | - |
| CHEMBL4277171 | — | — | 1 | - |
| CHEMBL4285717 | — | — | 1 | - |
| CHEMBL4283627 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291901 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4284048 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4280052 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4278165 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL4278775 | — | IC50 | - | — | - | |
| CHEMBL4286684 | — | IC50 | = | 349000.0 | nM | - |
| CHEMBL4290114 | — | IC50 | - | — | - | |
| CHEMBL4282248 | — | IC50 | - | — | - | |
| CHEMBL4283977 | — | IC50 | - | — | - | |
| CHEMBL4291839 | — | IC50 | - | — | - | |
| CHEMBL1543210 | — | IC50 | - | — | - | |
| CHEMBL4282057 | — | IC50 | - | — | - | |
| CHEMBL4289927 | — | IC50 | - | — | - | |
| CHEMBL259761 | — | IC50 | - | — | - | |
| CHEMBL4283944 | — | IC50 | - | — | - | |
| CHEMBL4294027 | — | IC50 | - | — | - | |
| CHEMBL4292989 | — | IC50 | - | — | - | |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 184000.0 | nM | - |
| CHEMBL1709376 | — | IC50 | - | — | - | |
| CHEMBL4278849 | — | IC50 | - | — | - | |
| CHEMBL4278444 | — | IC50 | - | — | - | |
| CHEMBL1529748 | — | IC50 | - | — | - | |
| CHEMBL4283627 | — | IC50 | - | — | - | |
| CHEMBL4285717 | — | IC50 | - | — | - | |
| CHEMBL4277171 | — | IC50 | - | — | - | |
| CHEMBL4285122 | — | IC50 | - | — | - | |
| CHEMBL2170108 | — | IC50 | - | — | - | |
| CHEMBL4276745 | — | IC50 | - | — | - | |
| CHEMBL4294214 | — | IC50 | - | — | - | |
| CHEMBL4289111 | — | IC50 | - | — | - | |
| CHEMBL4285482 | — | IC50 | - | — | - | |
| CHEMBL4280175 | — | IC50 | - | — | - | |
| CHEMBL4295028 | — | IC50 | - | — | - | |
| CHEMBL4287101 | — | IC50 | - | — | - | |
| CHEMBL1451226 | — | IC50 | - | — | - | |
| CHEMBL4290522 | — | IC50 | - | — | - | |
| CHEMBL4283334 | — | IC50 | = | 461000.0 | nM | - |
| CHEMBL4293926 | — | IC50 | - | — | - |