Assay Detail
Binding
CHEMBL4259980
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Transactivation of full-length FXR (unknown origin) expressed in HEK293 cells after 18 hrs by dual-glo luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.14 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281889 | — | — | 1 | 5.36 |
| CHEMBL4279753 | — | — | 1 | 5.22 |
| CHEMBL240597 | CHENODIOL | 4.0 | 1 | 5.15 |
| CHEMBL4289098 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281889 | — | EC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL4279753 | — | EC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL240597 | CHENODIOL | EC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL4289098 | — | EC50 | = | 14400.0 | nM | 4.84 |