Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4260596

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human coagulation factor 10a using Z-D-Arg-Gly-Arg-pNA.2HCl as substrate preincubated for 15 mins followed by substrate addition by UV absorption assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Semisynthesis of ent-norstrobane diterpenoids as potential inhibitor for factor Xa.
Wang J, Ma H, Fu H.
Bioorg Med Chem Lett (2018) 28 : 3813 -3815
PubMed 30340898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.84 8.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1269025 EDOXABAN 4.0 1 8.47
CHEMBL4278492 1 7.09
CHEMBL4293622 1 5.99
CHEMBL4289150 1 5.97
CHEMBL1089731 KIRENOL 1 5.59
CHEMBL4280434 1 5.52
CHEMBL4292565 1 5.25
CHEMBL4286054 1 5.24
CHEMBL3315237 1 5.14
CHEMBL4293958 1 5.07
CHEMBL1076911 DARUTIGENOL 1 4.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1269025 EDOXABAN IC50 = 3.4 nM 8.47
CHEMBL4278492 IC50 = 81.0 nM 7.09
CHEMBL4293622 IC50 = 1023.0 nM 5.99
CHEMBL4289150 IC50 = 1067.0 nM 5.97
CHEMBL1089731 KIRENOL IC50 = 2568.0 nM 5.59
CHEMBL4280434 IC50 = 3026.0 nM 5.52
CHEMBL4292565 IC50 = 5617.0 nM 5.25
CHEMBL4286054 IC50 = 5735.0 nM 5.24
CHEMBL3315237 IC50 = 7165.0 nM 5.14
CHEMBL4293958 IC50 = 8451.0 nM 5.07
CHEMBL1076911 DARUTIGENOL IC50 = 11418.0 nM 4.94