Assay Detail
ADMET
CHEMBL4260795
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Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.04 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644978 | — | — | 1 | 5.28 |
| CHEMBL4291048 | — | — | 1 | 5.25 |
| CHEMBL47050 | PENFLURIDOL | 2.0 | 1 | 5.21 |
| CHEMBL4293307 | — | — | 1 | 4.96 |
| CHEMBL4278465 | — | — | 1 | 4.94 |
| CHEMBL4282702 | — | — | 1 | 4.93 |
| CHEMBL1644980 | — | — | 1 | 4.92 |
| CHEMBL4287623 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644978 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4291048 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL47050 | PENFLURIDOL | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL4293307 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4278465 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4282702 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL1644980 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4287623 | — | IC50 | = | 14800.0 | nM | 4.83 |