Assay Detail
Binding
CHEMBL4261237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MBP-fused human NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 4.50 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285561 | — | — | 1 | 5.58 |
| CHEMBL1289862 | — | — | 1 | 5.25 |
| CHEMBL4288490 | — | — | 1 | 5.08 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 5.08 |
| CHEMBL4279510 | — | — | 1 | 4.62 |
| CHEMBL4292800 | — | — | 1 | 4.44 |
| CHEMBL4277615 | — | — | 1 | 4.34 |
| CHEMBL4277689 | — | — | 1 | 4.33 |
| CHEMBL4277321 | — | — | 1 | 4.28 |
| CHEMBL3558288 | — | — | 1 | 4.15 |
| CHEMBL4289116 | — | — | 1 | 4.13 |
| CHEMBL4281100 | — | — | 1 | 4.09 |
| CHEMBL4277834 | — | — | 1 | 4.06 |
| CHEMBL4291435 | — | — | 1 | 4.06 |
| CHEMBL4277391 | — | — | 1 | 4.00 |
| CHEMBL4293651 | — | — | 1 | - |
| CHEMBL4283057 | — | — | 1 | - |
| CHEMBL4290253 | — | — | 1 | - |
| CHEMBL4279593 | — | — | 1 | - |
| CHEMBL4286830 | — | — | 1 | - |
| CHEMBL4294730 | — | — | 1 | - |
| CHEMBL4283482 | — | — | 1 | - |
| CHEMBL4291325 | — | — | 1 | - |
| CHEMBL4281290 | — | — | 1 | - |
| CHEMBL4291908 | — | — | 1 | - |
| CHEMBL4290845 | — | — | 1 | - |
| CHEMBL4289583 | — | — | 1 | - |
| CHEMBL4287431 | — | — | 1 | - |
| CHEMBL4280607 | — | — | 1 | - |
| CHEMBL4295174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285561 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1289862 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4288490 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4279510 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4292800 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4277615 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4277689 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4277321 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3558288 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4289116 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4281100 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL4277834 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4291435 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4277391 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4294661 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL4290966 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4291251 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL4286541 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL4294428 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL4076483 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL4284515 | — | IC50 | = | 370000.0 | nM | - |
| CHEMBL4284646 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4292528 | — | IC50 | = | 400000.0 | nM | - |
| CHEMBL4288030 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL4280792 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4278858 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL4291991 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4291733 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL4277681 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1289198 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL4293651 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4283057 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL4290253 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL4279593 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4286830 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL4294730 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL4283482 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4291325 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4281290 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4291908 | — | IC50 | = | 440000.0 | nM | - |
| CHEMBL4290845 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL4289583 | — | IC50 | = | 470000.0 | nM | - |
| CHEMBL4287431 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL4280607 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL4295174 | — | IC50 | > | 500000.0 | nM | - |