Assay Detail
Binding
CHEMBL4261406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human DDR1 (492 to end residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation counting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Epithelial discoidin domain-containing receptor 1 (CHEMBL5319) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 5-(2,3-Dihydro-1 H-indol-5-yl)-7 H-pyrrolo[2,3- d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.46 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281823 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281823 | — | IC50 | = | 35.0 | nM | 7.46 |