Assay Detail
Binding
CHEMBL4262185
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Inhibition of Escherichia coli DNA gyrase assessed as inhibition of pUC19 supercoiling after 30 mins by agarose gel electrophoresis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.00 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4289833 | — | — | 1 | 7.33 |
| CHEMBL4293211 | — | — | 1 | 7.28 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 6.84 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.77 |
| CHEMBL4291620 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4289833 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4293211 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4291620 | — | IC50 | = | 170.0 | nM | 6.77 |