Assay Detail
Binding
CHEMBL4262200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive-inhibition of recombinant human N-terminal His-tagged soluble NPP1 (Val191 to Leu591 residues) expressed in mouse NSO cells using ATP as substrate by capillary electrophoresis method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NSO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.08 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1783609 | — | — | 1 | 6.67 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 4.89 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 4.78 |
| CHEMBL336208 | — | — | 1 | 4.60 |
| CHEMBL435402 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1783609 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Ki | = | 16500.0 | nM | 4.78 |
| CHEMBL336208 | — | Ki | = | 25300.0 | nM | 4.60 |
| CHEMBL435402 | — | Ki | = | 32800.0 | nM | 4.48 |