Assay Detail
Binding
CHEMBL4262211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive-inhibition of Wistar rat NPP1 using p-Nph-5'-TMP as substrate measured after 5 mins by UPLC method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL4295913) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.01 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 5.66 |
| CHEMBL4285222 | — | — | 1 | 5.01 |
| CHEMBL336208 | — | — | 1 | 4.69 |
| CHEMBL2407634 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132722 | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL4285222 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL336208 | — | Ki | = | 20500.0 | nM | 4.69 |
| CHEMBL2407634 | — | Ki | = | 20500.0 | nM | 4.69 |