Assay Detail
Binding
CHEMBL4262216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Uncompetitive-inhibition of recombinant human N-terminal His-tagged soluble NPP1 (Val191 to Leu591 residues) expressed in mouse NSO cells using p-Nph-5'-TMP as substrate after 15 mins by capillary electrophoresis method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NSO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL5925) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.68 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.97 |
| CHEMBL4285222 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL4285222 | — | Ki | = | 4090.0 | nM | 5.39 |