Assay Detail
Binding
CHEMBL4262218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NPP1 in Wistar rat C6 cells using [gamma-32P]ATP as substrate pretreated for 30 mins followed by substrate addition and measured after 90 mins by TLC analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (CHEMBL4295913) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.53 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69234 | — | — | 1 | 4.92 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69234 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL265502 | SURAMIN | IC50 | = | 72000.0 | nM | 4.14 |