Assay Detail
Functional
CHEMBL4262302
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Antiplasmodial activity against Plasmodium falciparum 3D7 after 3 days by SYBR green1 dye based assay
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 87 | 6.94 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.10 |
| CHEMBL1895209 | — | — | 1 | 7.75 |
| CHEMBL1902352 | — | — | 1 | 7.64 |
| CHEMBL3621482 | — | — | 1 | 7.58 |
| CHEMBL585180 | — | — | 1 | 7.55 |
| CHEMBL4282170 | — | — | 1 | 7.54 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.48 |
| CHEMBL576260 | — | — | 1 | 7.47 |
| CHEMBL4293660 | — | — | 1 | 7.43 |
| CHEMBL4283052 | — | — | 1 | 7.43 |
| CHEMBL570120 | — | — | 1 | 7.43 |
| CHEMBL4285784 | — | — | 1 | 7.42 |
| CHEMBL1875655 | — | — | 1 | 7.37 |
| CHEMBL569864 | — | — | 1 | 7.37 |
| CHEMBL3621580 | — | — | 1 | 7.34 |
| CHEMBL4291748 | — | — | 1 | 7.33 |
| CHEMBL4279738 | — | — | 1 | 7.31 |
| CHEMBL4293202 | — | — | 1 | 7.25 |
| CHEMBL4290452 | — | — | 1 | 7.25 |
| CHEMBL4283782 | — | — | 1 | 7.24 |
| CHEMBL4286827 | — | — | 1 | 7.21 |
| CHEMBL4283478 | — | — | 1 | 7.21 |
| CHEMBL4282380 | — | — | 1 | 7.17 |
| CHEMBL4282018 | — | — | 1 | 7.16 |
| CHEMBL4281519 | — | — | 1 | 7.15 |
| CHEMBL4278919 | — | — | 1 | 7.14 |
| CHEMBL4289892 | — | — | 1 | 7.13 |
| CHEMBL4278524 | — | — | 1 | 7.12 |
| CHEMBL4286868 | — | — | 1 | 7.11 |
| CHEMBL4287536 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1895209 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1902352 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3621482 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL585180 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4282170 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL576260 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4293660 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4283052 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL570120 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4285784 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1875655 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL569864 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3621580 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4291748 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4279738 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4293202 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4290452 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4283782 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4286827 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4283478 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4282380 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4282018 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4281519 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4278919 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4289892 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4278524 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4286868 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4287536 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4278552 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4294768 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4293277 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4290963 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4278847 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4283414 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3621579 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4293198 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL568963 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4281447 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4292811 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4286398 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4293686 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4281116 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4283093 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL1213959 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4293645 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4276894 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4294728 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4294283 | — | IC50 | = | 174.0 | nM | 6.76 |