Compound Detail
CHEMBL4281447
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Basic Information
| ChEMBL ID | CHEMBL4281447 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JKXZQZYHRDNQDE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
441.6
MW (Da)
3.55
ALogP
7
HBA
1
HBD
79.8
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.97 | 6.97 | 107.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 4.75 | 4.75 | 17800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 107.0 | nM | 6.97 | Antiplasmodial activity against Plasmodium falciparum 3D7 after 3 days by SYBR g... | 29308121 |
| HepG2 | IC50 | = | 17800.0 | nM | 4.75 | Cytotoxicity against human HepG2 cells after 3 days by CellTiter blue assay | 29308121 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29308121 | 10.1039/C7MD00052A | Unchecked | 2 |
| 29308121 | 10.1039/C7MD00052A | Histone-lysine N-methyltransferase EHMT2 | 1 |
| 29308121 | 10.1039/C7MD00052A | Plasmodium falciparum | 1 |
| 29308121 | 10.1039/C7MD00052A | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine