Assay Detail
ADMET
CHEMBL4262305
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Cytotoxicity against human HepG2 cells after 3 days by CellTiter blue assay
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 87 | 5.32 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4283478 | — | — | 1 | 5.75 |
| CHEMBL4283052 | — | — | 1 | 5.62 |
| CHEMBL3621482 | — | — | 1 | 5.58 |
| CHEMBL4294768 | — | — | 1 | 5.57 |
| CHEMBL4278552 | — | — | 1 | 5.55 |
| CHEMBL4286868 | — | — | 1 | 5.54 |
| CHEMBL4290963 | — | — | 1 | 5.54 |
| CHEMBL4286827 | — | — | 1 | 5.54 |
| CHEMBL4283782 | — | — | 1 | 5.54 |
| CHEMBL4289892 | — | — | 1 | 5.51 |
| CHEMBL4282018 | — | — | 1 | 5.48 |
| CHEMBL3621580 | — | — | 1 | 5.47 |
| CHEMBL4279738 | — | — | 1 | 5.44 |
| CHEMBL4282380 | — | — | 1 | 5.44 |
| CHEMBL4282170 | — | — | 1 | 5.42 |
| CHEMBL4290452 | — | — | 1 | 5.40 |
| CHEMBL4293277 | — | — | 1 | 5.39 |
| CHEMBL1875655 | — | — | 1 | 5.33 |
| CHEMBL1902352 | — | — | 1 | 5.33 |
| CHEMBL569864 | — | — | 1 | 5.32 |
| CHEMBL4278524 | — | — | 1 | 5.27 |
| CHEMBL1895209 | — | — | 1 | 5.26 |
| CHEMBL4293202 | — | — | 1 | 5.26 |
| CHEMBL3621579 | — | — | 1 | 5.25 |
| CHEMBL4278847 | — | — | 1 | 5.25 |
| CHEMBL4293660 | — | — | 1 | 5.23 |
| CHEMBL4278919 | — | — | 1 | 5.21 |
| CHEMBL4279942 | — | — | 1 | 5.20 |
| CHEMBL4283414 | — | — | 1 | 5.20 |
| CHEMBL4285784 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4283478 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4283052 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3621482 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4294768 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4278552 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4286868 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4290963 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4286827 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4283782 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4289892 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4282018 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3621580 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4279738 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4282380 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4282170 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4290452 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4293277 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1875655 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1902352 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL569864 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4278524 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1895209 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4293202 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3621579 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4278847 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4293660 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4278919 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4279942 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4283414 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4285784 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4290591 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4287536 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4287643 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL570120 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL4281447 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL1213903 | — | IC50 | - | — | - | |
| CHEMBL4287174 | — | IC50 | - | — | - | |
| CHEMBL4294728 | — | IC50 | - | — | - | |
| CHEMBL4281773 | — | IC50 | - | — | - | |
| CHEMBL4291579 | — | IC50 | - | — | - | |
| CHEMBL4291978 | — | IC50 | - | — | - | |
| CHEMBL4284108 | — | IC50 | - | — | - | |
| CHEMBL4292456 | — | IC50 | - | — | - | |
| CHEMBL1213959 | — | IC50 | - | — | - | |
| CHEMBL1213960 | — | IC50 | - | — | - | |
| CHEMBL4290900 | — | IC50 | - | — | - | |
| CHEMBL4276830 | — | IC50 | - | — | - | |
| CHEMBL4287479 | — | IC50 | - | — | - | |
| CHEMBL1213766 | — | IC50 | - | — | - | |
| CHEMBL4286468 | — | IC50 | - | — | - |