Assay Detail
Binding
CHEMBL4263002
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Inhibition of human MPO assessed as reduction in enzyme-mediated chlorination by measuring reduction in HOCl formation in presence of H2O2/NaCl measured at 30 secs time interval for 5 mins by APF dye based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.95 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278946 | — | — | 1 | 7.25 |
| CHEMBL333928 | — | — | 1 | 7.08 |
| CHEMBL278555 | — | — | 1 | 6.96 |
| CHEMBL4282403 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278946 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL333928 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL278555 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4282403 | — | IC50 | = | 320.0 | nM | 6.50 |