Assay Detail
Binding
CHEMBL4263012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MPO in human neutrophils assessed as reduction in PMA-stimulated HOCl production incubated for 3 mins and measured for 25 mins by luminol reagent based luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.65 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278946 | — | — | 1 | 6.00 |
| CHEMBL333928 | — | — | 1 | 5.30 |
| CHEMBL4282403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278946 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL333928 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4282403 | — | IC50 | = | 1700000.0 | nM | - |