Assay Detail
Binding
CHEMBL4263045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IKKalpha using ERLLDDRHDSGLDSMKDEE as substrate after 60 mins in presence of ATP by ADP-Glo kinase assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Hydroxy-<i>N</i>-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.45 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166474 | — | — | 1 | 4.45 |
| CHEMBL536151 | IMD-0354 | 1.0 | 1 | - |
| CHEMBL79004 | — | — | 1 | - |
| CHEMBL4287256 | — | — | 1 | - |
| CHEMBL4177097 | — | — | 1 | - |
| CHEMBL4279494 | — | — | 1 | - |
| CHEMBL4284710 | — | — | 1 | - |
| CHEMBL4294749 | — | — | 1 | - |
| CHEMBL4283501 | — | — | 1 | - |
| CHEMBL4280067 | — | — | 1 | - |
| CHEMBL4293673 | — | — | 1 | - |
| CHEMBL4283080 | — | — | 1 | - |
| CHEMBL4290266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166474 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL536151 | IMD-0354 | IC50 | > | 100000.0 | nM | - |
| CHEMBL79004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287256 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4177097 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4279494 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4284710 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4294749 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4283501 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4280067 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4293673 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4283080 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4290266 | — | IC50 | > | 100000.0 | nM | - |